Senior Investigator Profile

First NameMorris
Award StatusEmeritus
Current PostProfessor of Endocrine Hypertension
DepartmentWilliam Harvey Research Institute
InstitutionQueen Mary, University of London
NHS TrustBarts Health NHS Trust
Region NameLondon
Primary Research FieldCardiology & Cardiovascular Disease
Secondary Research FieldEndocrinology
BiographyMorris Brown is Professor of Clinical Pharmacology at the University of Cambridge. He specialises in hypertension (high blood pressure). The aim of his research has been to:develop tests for finding the uncommon patients whose hypertension can be explained and cured and deduce from such exceptions some general rules about choosing the right drug(s) for patients with the more common, complex condition of ‘essential hypertension’.  The research found that patients with single-cause hypertension lie at opposite extremes of a continuous spectrum and that most other patients have a mixture of too much salt and too much renin (the kidney hormone). Our mnemonic ‘AB/CD rule’ simplified drugs for hypertension into two broad categories, which target either salt or renin, and has helped the UK to leapfrog other Europe countries in hypertension control rates. Routine renin measurement is expected, after current research, to further transform diagnosis and treatment, enabling new drugs to be reserved for those who need them and old drugs to be used at more optimal dose.

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